List three addictive substances that are the “most harmful”, and explain why bas

List three addictive substances that are the “most harmful”, and explain why based on their effects on the brain, body and society. 
Define harm reduction using at least two contemporary examples that relate to addiction. Then explain why harm addiction is controversial, yet important.
Compare the similarities between the prohibition Era and the current War on Drugs. Then explain the limitations of prohibitive attempts at curbing substances used historically and today. 
Explain the biological causes of addiction and include a description of the reward pathway in the brain, and how this induces a “high”. 

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